In the last four years, the Foundation has allocated over $1 million to translational research projects at the Jones Institute of Eastern Virginia Medical School. These projects have been conducted by clinical physicians in the Institute and scientists recruited for their knowledge and expertise in assisted reproductive techniques.

Research continues at the Jones Institute where investigators are working on these projects:

Identification of Markers of Human Embryo Developmental Potential in IVF
Researchers are attempting to optimize the selection of a single viable embryo with the highest developmental potential in order to improve the chance for implantation and pregnancy, and also to decrease or even eliminate multiple gestations.  This project is based on the utilization of the highly specific and sensitive techniques of proteomics and metabolomics.

The Human Endometrium During the Window of Implantation
Despite the dramatic achievements in assisted reproductive technology, only 20 - 30% of embryos transferred in IVF actually implant. This raises the question of whether implantation failure is one of the most important etiologic factors in human infertility.  One of the goals of another current and ongoing study is to improve the knowledge of implantation of the embryo in the uterus, and decipher the key molecules involved.  A novel three-dimensional endometrial culture model has been developed that will allow studying trophoblast attachment and invasion of the simulated endometrium

Oocyte Failure
The human egg, regardless of its age, varies greatly in its pregnancy potential.  Another study at the Institute examines the aging egg, and the possible ways to "rescue" poor quality eggs, with hopes that the results could benefit women who are older and wish to bear children later in their reproductive years.